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Vandenberghe et al reported that CYP2D6 but not NR1/2 , POR , PPAR , ABCB1 , CYP3A plays an important role in risperidone, 9-hydroxyrisperidone, and active moiety plasma concentration

It also helps modulate GABA, a calming neurotransmitter that prevents overstimulation in the brain

This allowed us to explore the potential effects of genetic variants on nearby genes and regulatory elements, providing a broader understanding of the genetic architecture underlying the trait of interest

The pulmonary environment imposes distinct metabolic demands on resident macrophages

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In Parkinsons disease (PD), astrocytic mitochondrial dysfunction disrupts the clearance of -synuclein through the ubiquitin - proteasome system and autophagy pathways, promoting the formation of Lewy bodies