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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

Its primary mechanism is believed to pivot around enhancing lipolysis, the breakdown of fat, and suppressing lipogenesis, the process of fat accumulation [More et al., 2014]

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Lykkesfeldt, J., & Tveden-Nyborg, P