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1 Introduction Among these, disordered protein metabolism and negative nitrogen balance are closely linked to muscle wasting, delayed wound healing, increased risk of infection, prolonged mechanical ventilation, and impaired rehabilitation (14)

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Inference of the model parameters was performed in the framework of Bayesian inference, wherein random draws of the posterior distribution were obtained using Sequential Monte Carlo (SMC), see Svensson and Schn (2017) and The state space model and posterior model parameter samples were then used to construct posterior predictive distributions of the response of each readout to a given test material for a given concentration and timepoint (see Figure 4)

(237) Younossi, Z