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Ipamorelin has a half-life of approximately 2 hours and is distinguished from other GH secretagogues like GHRP-2 and GHRP-6 by its selectivity: it releases GH without significantly elevating cortisol, prolactin, or ACTH levels

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Beneficial effects of IGF-I treatment in ALS have been demonstrated both in vivo and in vitro , from which IGF-I has been postulated as an important factor for the maintenance and survival of motor neurons in the spinal cord by activating clue pathways as PI3K/Akt and p44/42 MAPK[333] and ameliorating the superoxide effect[334]

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