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Augmented Hyper-CVAD in acute lymphoblastic leukemia (ALL): The MDACC experience with intensified L-asparaginase and vincristine in adult ALL salvage

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A future challenge is to identify highly selective and potent, small-molecule drugs capable of activating CaMKK2 in the brain, which can then be validated preclinically in human induced pluripotent stem cell (iPSC) and animal models of bipolar disorder

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However, this clinical trial had a limited sample size (placebo: 23 patients, riluzole: 25 patients), which means that further large-scale clinical studies are needed to clarify the effect of riluzole

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