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Abnormal Ca 2+ handling led to mitochondrial membrane permeabilization with consequent release of either mtDAMPs and MDVs to promote and sustain the inflammation or cytochrome c and pro-apoptotic factors to active caspases and trigger apoptosis, exacerbating the disease progression [24,25,26]

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In poultry, three principal categories of selenoproteins influence physiological function: thioredoxin reductases (TrxR), iodothyronine diiodinases, and glutathione peroxidases (GSH-Px)

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