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Many of these therapeutic strategies applied in CKD management have focused mainly on lifestyle changes (including dietary patterns and exercise), biotics intervention (probiotics, prebiotics, and synbiotics), and FMT (Figure 3)

Various structurally related analogs of lipoic acid were developed, some of which are able to cross the bloodbrain barrier (Guillonneau et al., 2003

Gently squeeze the tube to fill 1 teaspoon, hold under tongue for 30-60 seconds, then swallow

Cell culture studies further reveal lowered lipid peroxidation and markers of reactive oxygen species following Epithalon exposureindicating a protective effect on cellular membranes and biomolecules

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