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Under normal physiological condition, only a handful of hepatocytes are in proliferation state, but exhibit strong regenerative ability once stimulated, either through tissue damage or tissue injury

Additionally, testosterone can be converted to its highly androgenic metabolite, DHT, and to E2 in the adipose, ovaries, and brain, through 5-reductase and aromatase, respectively [48,49,50]

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The apoE / mice fed with dietary TMAO for 8 weeks were found to have increased atheromatous plaques in the aorta and elevated serum lipids compared to the control group, which was demonstrated to be due to the inhibition of hepatic bile acid synthesis in mice possibly by downregulating Cyp7a1 (i.e., cholesterol 7-hydroxylase, the key regulatory enzyme of hepatic bile acid biosynthesis) (Koeth et al

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Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)