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However, when GPX4 is deactivated or GSH levels are depleted in cells, phospholipid peroxides (PLOOH) accumulate, leading to the production of lipid radicals, such as lipid peroxyl radicals ((P)LOO) and alkyl radicals ((P)L), through iron-dependent free radical chain reactions

Several inflammatory and OS markers were decreased in healthy individuals after they were given melatonin prior to the infusion of LPS (Alamili et al., 2014)

doi: 10.3389/fcimb.2024.1348713 Received 03 December 2023 Accepted 15 February 2024 Published 06 March 2024 Volume 14 - 2024 Edited by Hjalmar Bouma, University Medical Center Groningen, Netherlands Reviewed by Mirasari Putri, Bandung Islamic University, Indonesia Yuchang Wang, Huazhong University of Science and Technology, China Updates Copyright 2024 Sahoo, Wong, Patani, Paital, Yadav, Patel and Jergens

doi:10.1097/TP.0000000000000183

In this study, the genes critical for reducing opacity were defined as those whose expression levels decreased by over 10% from Galactose to Glutamate, with the increase in gene expression from Control to Galactose considered as 100%

Antioxidants 12 , 831 (2023)