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Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A et al (2011) Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia

10.1016/s2589-7500(20)30107-2 125

P.KotankoP.ScholsA

The iodoTMTsixplex reagents consist of six different isobaric isomers that can react with the sulfhydryl (-SH) group of protein via irreversible labeling step by forming an iodoacetyl-activated covalent bond (Figure 3C, and the chemical structures of iodoTMTsixplex reagents with the distribution of isotopes and their reaction with reduced Cys are shown in Figure 4C

Moreover, PER2 has been reported to form a trimeric complex with p53 and the oncogenic mouse double minute-2 homolog protein (MDM2), the p53s negative regulator, thereby increasing p53 stability by blocking Mdm2-dependent ubiquitination and transcription of p53 target genes 36

We also determined whether DMB could inhibit TNBS-induced proinflammatory cytokines, endothelial nitric oxide synthase (eNOS), iNOS, TNF-, COX-1, interleukin-6 (IL-6), and COX-2 gene expression