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Antioxidants are substances that reduce oxidative stress by combating free radicals in the body

In the CC of cuprizone-treated mice the expression of the IGF-1 mRNA started to be up-regulated after 2 weeks of cuprizone feeding (Gudi et al., 2011) and peaked at weeks 45 corresponding to the maximal demyelination, proliferation of OPC and onset of their differentiation (Gudi et al., 2011)