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This variation between studies may be due to the different puff routines used to generate the tobacco smoke (HCI vs ISO), aging of smoke particles over the puff routine (4 vs 8 mins) and dilution ratios in the smoke bags (75 vs 33)

Second, the quantitative measurement of serum cotinine levels as an objective indicator of tobacco smoke exposure is another strength of the study, specifically avoiding the risk of misclassification or underestimation of tobacco smoke exposure