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In contrast, angiogenic factors promote changes in extracellular factors and contribute to immunosuppressive TME formation, such as peripheral dendritic cell (DC) maturation, inhibition of T-cell activation, and polarization of macrophages toward the M2-like tumor-associated phenotype 55

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Peptide signals can elevate homing factors such as SDF-1 and induce the expression of niche signals that direct stem cells toward epithelial or germ-line cell fates

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