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Eur J Pharmacol 218:339341 Xie J, Sun B, Du J et al (2011) Phosphatidylinositol 4,5-bisphosphate [PIP(2)] controls magnesium gatekeeper TRPM6 activity

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The primary ROS is often O 2 that is produced either by plasma membrane-located NADPH oxidase or in electron transfer chains of mitochondria (Torres et al., 2 O 2 are converted in enzymatic or non-enzymatic steps

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Similarly, in a liver injury model induced by bile duct ligation, injection of FGF19 can also reduce the area of hepatocyte necrosis (Modica et al., 2012)