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Together, our data indicate that not only the mutant or WT status of Rb but also the expression levels of FZR1 and functional activity of the APC/C FZR1 E3 ligase will determine how cancer cells respond to CDK4/6 inhibitor treatment

doi:10.1007/s12016-009-8168-4

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These effects seem to be more prominent in ambulatory than in non ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down

Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system