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We have found that in many cases, neurotoxic load in the body is significant because neurotoxicity symptoms often mimic mental health symptoms and disorders

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Dolphin, D., Poulson, R

617 The metabolite -KG from glutamine breakdown has been identified as a crucial player involved in epigenetic reshaping mediated by glutamine breakdown, acting as a co-factor for peroxidases and regulating histone and DNA methylation levels in glutamine breakdown-mediated epigenetic reshaping

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A proposed mechanism for the insulin resistance implicated in metabolic syndrome, and subsequently in type 2 diabetes, is through oxidative stress