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This cell-type blind spot has created uncertainty in therapeutic target selection within the TBI cell death network

Figure 4 3.7.3 Others Chronic inflammation is an important pathogenic factor in the liver and accelerates the progression of MASLD and MASH, serum levels of many inflammatory markers and mediators, including C-reactive protein (CRP), tumor necrosis factor (TNF), IL6 and IL8, Interleukin-1 receptor antagonist (IL1RA) and C-X-C motif chemokine ligand 10 (CXCL10), have been examined as diagnostic markers

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Subsequently, three additional NAs with known mutagenicity and carcinogenicity were tested in the in vitro liver cell models, but not in PCLiS