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Targeted phosphoinositide profiling further revealed distinct phosphatidylinositol/phosphatidylinositol phosphates (PI/PIP) signatures relative to murine BV2 cells and dynamic responsiveness to SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1) modulation, implicating the phosphoinositide 3-kinase (PI3K)-SHIP1-TREM2 regulatory axis as a tractable signaling pathway in this human microglial model (222)

N.TajberL.et al (2013)

Eur J Neurol 2005

Science (80-) 327:833834 Figueiredo MVB, Seldin LFF, de Araujo Mariano RLR (2010) Plant growth promoting rhizobacteria: fundamentals and applications

Exogenously, they arise from exposure to environmental factors like ultraviolet (UV) radiation, pollution, tobacco smoke, and industrial chemicals [3]

The decline of macrophage phagocytosis was linked to changes in the aged tissue microenvironment, including increased immune cells and IL-10 from B cells