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Amino acid transporters in cancer and their relevance to glutamine addiction: novel targets for the design of a new class of anticancer drugs

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Therefore, mitochondrial alterations have been implicated in the etiology of many diseases including cancer

TABLE 1 Pharmacological strategies for inhibiting glutamine metabolism in cancer cells

However, some people have genetic or medical conditions that prevent their bodies from meeting the necessary amount

Affinity purification performed by gravity using TALON resin (Clontech), anion exchange performed using HiTrapQ FF (GE Healthcare), size-exclusion chromatography performed using Superdex 200 10/30 prep grade (GE Healcare) the later two performed using KTA FPLC platform