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Folate becomes 5-methyltetrahydrofolate to help in the methylation of homocysteine to methionine

Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al

BMJ 2021:372

Although our study mainly focused on the protective role of MeCbl in inhibiting GSDME-mediated liver failure, it is important to note that GSDME is universally expressed in diverse other organs and may represent a key executor in mediating multiple pyroptotic organ damage