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Cigarette smoke contains substances such as polycyclic aromatic hydrocarbons that induce liver enzymes, particularly cytochrome P450 1A2 (CYP1A2)

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While Imperial had success in the fledgling cigarette market in Ireland, they failed to make inroads in the more popular pipe-tobacco sector, which commentators felt was due to the superior Irish product and loyalty to Irish producers in a period of revived Irish nationalism