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In particular, a peptide inhibitor of JNK kinase-mediated mitochondrial cell death pathway, D-JNKI-1 peptide, has shown promises in protecting the cochlea against noise-induced and aminoglycoside induced HC loss when delivered directly into the scala tympani or locally to the round window membrane (Wang et al., 2003b, 2007

139 As HIV progresses, antioxidant levels decline

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Furthermore, studies have identified Nrf2 as a promising antioxidant target for depression treatment (Liao et al., 2020)

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