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Description

2019;28(5):1268e816

Published May 20, 2020

N.WardE

R.AbdallahA

By temporally mapping these alterations to a post-maturational window (P12 in SMA mice), we highlight a phase in which functionally mature INs begin to fail, likely as a consequence of SMN deficiencyinduced disruption of the neuronastrocyte GGG cycle, while offering a plausible developmental origin for the cortical dysfunction observed in SMA