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However, it was found that cisplatin-induced apoptosis is related to disbalance in the mGSH/GSSG ratio, decrease in NADPH(H + ) content, and oxidative damage of cardiolipin and aconitase, which disturbs the functioning of mitochondria and activates caspase-3 [78, 79]

doi: 10.1186/2045-9912-2-15 57 ItohT.FujitaY.ItoM.MasudaA.OhnoK.IchiharaM.et al

Proceedings of the National Academy of Sciences of the United States of America 103 , 46284633 (2006)

Glutathione: The master antioxidant of the body

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GL was responsible for literature search methodology, validation of the literature and writing the original draft