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A more recent paper combined the use of cryo-EM and mass spectrometry on a recombinant AR protein that was bound to a canonical ARE [97]

Annu Rev Immunol (2015) 33:169200.10.1146/annurev-immunol-032414-112334 8 MilesJJDouekDCPriceDA

Multiple metabolic pathways associated with glutamine, such as glutamine-mTOR signaling, glutamine-glutamate-other amino acid pathway, glutamine-ISR stress pathway, and glutamine-autophagy pathway, have been observed to modulate the differentiation of Th17 and Tregs [136]

When the therapy, on patients undergoing treatment, was terminated there was a drop in the analyzed parameters, which fell to pretreatment values at the subsequent controls