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The protein expression levels of tight junction associated protein-1 (ZO-1), Occludin, inflammatory factors interleukin (IL)-6, IL-1 and tumor necrosis factor (TNF)-, SIRT1, STAT3, p-STAT3, and retinoic acid receptor-related orphan receptor gamma t (RORt) were detected by Western blot

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It also supports positive ageing, particularly for brain and eye health

Early signs include tingling or 'pins and needles' in the feet and hands, numbness in the extremities, burning pain (often worse at night), balance problems, and muscle weakness