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No hepatic safety signal has been identified, a finding of particular importance given the hepatotoxicity that led to the discontinuation of competing oral GLP-1 programs

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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

The supervised approach is what lets you get the upside while someone qualified is watching for anything that doesn't fit

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The OPLS-DA yielded a regression model with high-quality parameters (R2 = 0.93 and Q2 = 0.71, CV-ANOVA test, P = 0.00055)