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As a result, after the thiamine administration, the injured and non-operated groups are similar not only in the levels of the NO -related amino acids (Figures 2AE) but also in their ratios (Figures 2FJ), suggesting a positive effect of thiamine on the injury-induced perturbations in NO metabolism

By Value 8.3.2.2

The Lancet (2014) 8

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Researchers assume this is due to the changes to neurotransmitter levels.[ref] Beyond those rare and severe deficiency symptoms, a decrease in tetrahydrobiopterin can also play a role in the conditions listed above, such as altered nitric oxide creation, heart disease, immune system changes, and neurological conditions

10.1046/j.0022-3042.2002.00744.x 196 LiuZ.SongY.LiD.HeX.LiS.WuB.et al (2014)