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[12] Transaminases are cytosolic enzymes present in all cells, but are particularly abundant in the liver, kidney, intestine, and muscle

Since, AGEs are dicarbonyls, formation of a covalent adduct with one lysine residue on a polypeptide chain generates a free carbonyl group which can further form another covalent adduct with the lysine residues on the other polypeptides developing a cross-linked oligomer

Vitamin C berperan sebagai antioksidan dan membantu dalam proses pembentukan kolagen

Rodrigues S, Alves RS, Antunes SC

These different studies support the contention that peroxynitrite formation due to NO and superoxide overproduction in the reperfused intestine induces gut damage and inflammation, notably by stimulating the mechanisms recruiting activated phagocytes, and also results in gut barrier failure by triggering the activation of PARP within the gut mucosa

Glycogen synthetase kinase 2 (GSK 2)