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14 Researchers have investigated several ways to alleviate MTX-induced hepatotoxicity, including phosphodiesterase-4 (PDE4) inhibitors

To reduce the incidence of emergence reactions, animals should not be stimulated by sound or handling during the recovery period

13 C NMR (151 MHz, DMSO-d 6 ) 178.3 (PtO C (=O)CH 3 ), 173.2 (B-10), 163.9, 163.8 (d, B-9), 163.4, 163.4 (PtO C (=O) 2 ), 61.1, 60.8 (D-2), 53.4, 53.2 (d, B-4), 52.9, 52.9 (d, B-7), 50.7, 50.6 (d, B-5), 31.0, 30.9 (D-3), 24.7, 24.6 (d, B-6), 24.1, 24.0 (d, B-3), 23.5, 23.5 (D-4), 22.9 (PtOC(=O) C H 3 ), 21.1 (B-2), 13.6 (B-1)

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However, results remain preliminary, and the role of 5-amino-1MQ in this area of research has not been fully established

Biomed Pharmacother = Biomedecine Pharmacotherapie (2020) 121:109604