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JAMA Pediatr 169(11):10531060 Saber S, El-Kader EMA (2021) Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats

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Front Pharmacol (Internet) 6, 286.CrossRefGoogle ScholarPubMed Zhai, Z, Fu, Y, Zhang, X, et al

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Furthermore, the compensatory hyperinsulinemia resulting from adipose dysfunction stimulates de novo lipogenesis in hepatocytes while simultaneously impairing muscle glucose uptake, creating a pathological metabolic state that propagates systemic insulin resistance (157)

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