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Graphical Abstract Access this article Similar content being viewed by others Data Availability No datasets were generated or analysed during the current study

2011;6(5):e19927

Meanwhile, the underlying issuea genetic bottleneck in catecholamine clearanceremains unaddressed

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The chronic activation of the HPA axis due to stress can lead to elevated levels of cortisol, a hormone known to have neurotoxic effects (Mbiydzenyuy and Qulu 2024)

When ROS increases, the synthesis of mitochondrial fusion-related proteins will be inhibited, thus promoting mitochondrial fission, which in turn may lead to more ROS production and severe mitochondrial dysfunction