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this leads to increased genetic instability and heightened activity of DNA repair mechanisms, such as overexpression of poly (ADP-ribose) polymerase

doi: 10.1007/s10096-015-2333-x 71 YangBHouSHuangSLiHLiY

O.GonalvesC.-A.Quincozes-SantosA.et al (2017)

Novel serological markers of cccDNA transcriptional activity: hepatitis B core-related antigens (HBcrAg) and pre-genomic HBV RNA (pgRNA) are relevant in separating HBeAg-negative patients (infection vs

Patients were divided into two groups, those with cirrhosis secondary to NASH, and those with cirrhosis secondary to other etiologies (Non-NASH)

METTL1 decreases FTH 1 expression by enhancing m7G modification of FTH 1 and pri-miR-26a, and thus increase ferroptosis, thereby reducing chemoresistance of osteosarcoma, so targeted therapy on METTL1 may be a potential and promising treatment strategy for osteosarcoma [111]