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The REW variant also showed enhanced binding to mouse C1q (Fig

BPC 157 What's Your favorite Peptide?

Wardman P

Thus, the transition from crystal deposition to acute inflammation can be conceptualized as a two-hit process: First hit: MSU crystal deposition on cartilage surfaces activates synovial fibroblasts to release CCL2/MCP-1, recruiting monocytes and establishing subclinical inflammation