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Research Highlight Published: NAFLD Nature Reviews Gastroenterology & Hepatology volume 12 , page 123 (2015) Cite this article 4855 Accesses 34 Citations 11 Altmetric Metrics details Subjects New research shows that NASH is associated with increased intestinal permeability and indicates that an early phase of liver injury and inflammation contributes to this breach in the intestinal barrier

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Moreover, HIF expression has been observed in chondrocytes and osteoclasts, indicating its ubiquitous presence in synovial tissues (129)

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This pre-phosphorylation is tied to the lower glycolytic conversion of phosphoenolpyruvate (PEP) to pyruvate through two phosphocarrier proteins (PtsI [EI] & PtsH [HPr-His])

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doi: 10.1371/journal.pone.0025792

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Strategies to address this include designing biocompatible dendrimers, adjusting surface charges, and applying chemical modifications to mitigate toxicity for clinical applications [201]

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