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Nutrients and Metabolic Research, 45(3), 267-285

As cardiac IRI is tightly linked to the pro-inflammatory cascades driven by cytokines, neutrophils, and immune signalling, reperfusion-induced release of DAMPs activates pattern recognition receptors, amplifying cytokine production and neutrophil infiltration [27,33]

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Fusion proteins wherein an scFv is linked to a second polypeptide, such as a toxin or fibrinolytic activator protein, have also been reported (Holvost et al, 1992

a higher proportion of patients with low baseline ALP leads to higher response rates in both investigational and placebo groups