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Following activation, GPER increases the expression of fatty acid metabolism genes, promoting energy release [31, 98]

Although unlikely, the testosterone supplementation might have influenced behavioral changes such as physical activity levels whereas the placebo group spontaneously reduced their physical activity levels despite being instructed to maintain normal physical activity

10.1038/nn.3526 246 SarmaB

Nutrition 15 , 177179 (1999)

Ovarian aging: molecular mechanisms and medical management