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In mouse models, copper deficiency impairs cardiac function, manifesting as reduced diastolic and systolic performance alongside a diminished inotropic response to beta-adrenergic stimulation, which compromises the heart's ability to adapt to stress [206]

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After a delay of 0 to 2 days, all patients experienced a rapid 1 st HDV decline phase (median slope of 0.14 log/day [IQR:0.06]), followed by a viral plateau (flat-partial response, FPR, n=8

GSH plays as role of antioxidant and is involved in ROS homeostasis and detoxification processes foreign toxic metals (xenobiotics including major HMs) that lead to enhanced HMs tolerance in plant cells (Figure 3 and Table 2)