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Initial Treatment in Combination with Pembrolizumab and Platinum The efficacy of pemetrexed in combination with pembrolizumab and platinum chemotherapy was investigated in Study KEYNOTE-189 (NCT02578680), a randomized, multicenter, double-blind, active-controlled trial conducted in patients with metastatic non-squamous NSCLC, regardless of PD-L1 tumor expression status, who had not previously received systemic therapy for metastatic disease and in whom there were no EGFR or ALK genomic tumor aberrations

The single stranded DNA is replicated to double stranded DNA by cellular DNA polymerases

10.1292/jvms.71.737 116

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According to the Global Burden of Disease (GBD) Study 2019, the number of individuals living with PD more than doubled from 2.5 million in 1990 to over 6.1 million in 2016, with projections exceeding 12 million by 2040 (Zhong and Zhu, 2022)