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doi: 10.1016/j.jsbmb.2008.03.027 144 QureshiRPicon-RuizMAurrekoetxea-RodriguezINunes de PaivaVDAmicoMYoonHet al

TMAO activates the NLRP3 inflammasome through three distinct signaling mechanisms: mitochondrial dysfunction induced by Rac1-NOX2-dependent ROS production, which causes cytosolic release of oxidized mtDNA

doi: 10.4103/0019-5154.57602

The TGF- pathway is often dysregulated during aging, resulting in reduced collagen production, increased activity of extracellular matrix-degrading enzymes, and impaired cell regeneration

Matsumoto, K., Funakoshi, H., Takahashi, H

In Marfan syndrome, a reduction of the skins elasticity happens, and Cushings syndrome may make the body produce a certain hormone at a higher level that causes rapid weight gain