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10.1007/s00284-022-02825-5 103

Funding This study was supported by the State Key Laboratory of Trauma, Burn and Combined Injury (SKLYQ202002 to YC), Southwest Hospital (SWH2018BJKJ-05 to YC), National Natural Science Foundation of China (82030036 to HF), and Chongqing Talent Program (4139Z2391 to HF)

Personalization in Timing The best time for you depends on your specific health goals and lifestyle: For Active Lifestyles: If you need sustained energy for physical or mental tasks, the morning is likely best

management mainly consists of supportive care and discontinuation of triggers

The question of whether fixed categories of astrocytes exist was better explained after identifying the limitations of binary divisions of reactive astrocytes into neurotoxic vs

**Patch Test:** Before applying to your entire face, perform a patch test on a small, inconspicuous area of your skin (e.g., behind the ear or on the inner forearm), and wait 24 hours to check for any adverse reactions