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This signaling pathway activates the arachidonic acid cycle, increasing PGE2 release and driving further immunosuppression [37]

Fu et al., 2020)

Thirdly, GPX4 levels decreased in cartilage from the OA animal models, and knockout of GPX4 exacerbated mice experimental OA process [111]

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The pathophysiology of oxidative stress and inflammation is essential in understanding the role of antioxidants and anti-inflammatories as immunomodulators