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In a 2020 case study , researchers reported a young woman treated with multiple daily doses of 1 milligram (mg) of cyanocobalamin (synthetic vitamin B12) for severe pernicious anemia (lack of red blood cells due to vitamin B12 deficiency)

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Over-the-counter antihistamines may also ease symptoms, but be cautious about long-term use

those with normal levels are unlikely to see significant changes in energy or well-being from supplementation