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Modification to the Overall Hospital Quality Star Rating Methodology In the CY 2025 OPPS/ASC final rule with comment period (89 FR 94514 through 94521), we presented three options and analyses (utilizing data from the July 2023 publication of the Overall Hospital Quality Star Rating) for potential methodological updates to emphasize Safety of Care in the Overall Hospital Quality Star Rating and summarized the public comments received

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The Fundamental Divide: Two Completely Different Mechanisms The three compounds split into two mechanistic families: Family 1 Growth-hormone fragment (direct lipolysis): AOD-9604 acts directly on adipose tissue, studied for stimulating lipolysis and inhibiting lipogenesis, independent of the IGF-1 receptor