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Consequently, these compounds have not undergone systematic and standardized experimental pharmacokinetic research on new drugs

When applied topically or ingested in various forms (such as tablets, creams, soaps, or even injections), it works wonders on the skin

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Its important to note that even if a molecule possesses the above characteristics, it may not necessarily cross the BBB easily, as the BBB is highly selective, allowing only specific molecules to pass

These cytokines promote cartilage degradation, synovial inflammation, abnormal bone remodeling, and neuropathic sensitization, collectively driving the initiation, progression, and pain associated with OA 10 .Targeted anti-inflammatory therapies represent a critical direction in OA treatment