Alcohol disrupts neurotransmitter regulation, especially glutamate and GABA, and acamprosate helps normalize that balance once abstinence begins
In this study, RVX reduced testicular MDA and elevated GPx content, revealing that its anti-oxidant effect mediated its protection against testicular IR
It does not directly stimulate fibroblast proliferation under normal culture conditions, but substantially increases fibroblast survival under hydrogen peroxide-induced oxidative stress acting as a cytoprotective enhancer of the endogenous repair response rather than a direct mitogenic agent
The US FDA New Drug Approvals in January 2026 Shots: Approval numbers were lower, but the impact remained strong the FDA cleared one new drug in January 2026 versus three in January 2025, reflecting continued innovation in areas of high unmet need Zycubo from Sentynl Therapeutics was approved for pediatric Menkes disease, offering a targeted treatment for this rare, life-threatening genetic copper deficiency disorder Clinical results were striking, showing about an 80% reduction in risk of death and a major survival gain of 177.1 months versus 17.6 months in untreated patients, with Zycubo providing daily subcutaneous bioavailable copper replacement Company: Sentynl Therapeutics Product: Zycubo Active Ingredient: Copper Histidinate Disease: Pediatric Menkes Disease Date: Jan 12, 2026 Shots: The US FDA has approved Zycubo (copper histidinate) for the treatment of pediatric patients with Menkes disease Approval was supported by clinical data showing improved OS with early Zycubo treatment vs an untreated external control, reflecting ~80% reduction in the risk of death & a mOS of 177.1 vs 17.6mos
Improvement in VA was seen in 14 (70%) eyes
Similar to the effects on synaptic plasticity, different Rho GTPases play differential roles in memory
