tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate DBCO Trametinib binds KRS-MEK and disrupts

Trametinib binds KRS-MEK and disrupts RAF-MEK

Product Name dCeMM2 Synonyms CAS Number 296771-07-8 Related CAS Molecular Formula C16H11ClN6OS Molecular Weight 370

It has been used as a fluorescent substrate/probe to study the distribution and mechanism of action of multidrug resistance-associated protein 2 (Mrp2)

827 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

42 SMILES Cl

tert-butyl 2-[4-(piperazin-1-yl)piperidin-1-yl]acetate DBCO Trametinib binds KRS-MEK and disruptsNitrogen Heterocycle Based Linker (NHBL). Binfunctional amine carboxylic acid linker. Product Name tert butyl 2 [4 (piperazin 1 yl)piperidin 1 yl]acetate Synonyms 1 Piperidineacetic acid, 4 (1 piperazinyl) , 1,1 dimethylethyl ester CAS Number 149554 09 6 Related CAS Molecular Formula C15H29N3O2 Molecular Weight 283. 416 SMILES CC(C)(C)OC(=O)CN1CCC(CC1)N1CCNCC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated