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Redox Responsive Hyaluronic Acid Nanogels for Treating RHAMM (CD168) Over-Expressive Cancer, Both Primary and Metastatic Tumors

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Compared with the blank group and the SF/HAMA group, the SF/HAMA/DDM group had a larger staining area, the staining intensity increased, the positive area widened with increasing DDM content, and the SF/HAMA/DDM-50 group presented the most pronounced increase

There are studies showing that TCR stimulation induces the generation of an enormous amount of ROS, thus resulting in the activation of transcription factors nuclear factor of activated T cells (NFAT), activator protein-1 (AP-1), and nuclear factor kappa light chain enhancer of activated B cells (NF-kB) (80)

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Circulation , 143 , e984e1010