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All authors contributed to the editing process and read and approved the final manuscript

The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) (72, 73)

and Pharmacotherapy = Biomedecine and Pharmacotherapie 137, 111286

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Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits