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Pruritus affects 20% of patients with NF1 and considerably impacts their quality of life.21 The itching has been attributed to increased mastocytes in the skin, but there do not appear to be any differences in plasma levels of histamine in patients with itching compared to the general population.22 Many patients do, however, have pruritus localized in the neurofibromas, where elevated mastocytes have been detected

doi:10.1182/blood.V36.6.797.797

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doi: 10.1016/j.nutres.2022.10.002 93 McGrathE